Selected African Plants and their Alkaloids in the Management of Alzheimers' Diseases

Oluyori, Abimbola Selected African Plants and their Alkaloids in the Management of Alzheimers' Diseases. NIPES-Journal of Science and Technology.

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Abstract

Alzheimer's disease is one of the most common Neurodegenerative diseases, which not only poses a serious burden on global health but also affects the quality of human life and cognitive functions. Changes in the personality, psychiatric issues, memory loss, speech and movement impairments characterize it. The precise root cause of Alzheimer's disease is yet unknown, but current -amyloid protein, inhibit acetylcholinesterase and maintain neurotransmitter levels. However, most of these medications only manage the symptoms of Alzheimer's disease. Hence, the need for an alternative treatment that could effectively cure the disease. The therapeutic application of some medicinal plants has been found to be effective in the traditional medicine system for the treatment of various diseases. Studies revealed that many extracts from some African plants contain alkaloid bioactive compounds which showed a significant neuroprotective effect in inhibiting acetylcholinesterase enzymes and suppressing the formation of amyloid fibrils, which are major hallmarks of the disease. This present work seeks to appraise several studies on the efficacy of some selected African plant species, with a focus on the role of alkaloids in the treatment of Alzheimer's disease. Ethnopharmacological uses of these plants, their phytoconstituents and pharmacological potentials are extensively summarized.

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