Phytochemical and In vivo Anti-Plasmodial Investigation of Raphia Palm Seed

Oluyori, Abimbola Phytochemical and In vivo Anti-Plasmodial Investigation of Raphia Palm Seed. Tropical Journal of Natural Product Research.

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Abstract

The ethanol extract of Raphia palm seed (RPSE) was subjected, for the first time, to phytochemical and antiplasmodial investigation to establish its curative potency in Plasmodium berghei-infected mice. The phytochemical analysis showed that the total alkaloid content was 20.98 mg/ 1.00 g of the endocarp while the total flavonoid and total phenolic contents were 0.7061 mg Rutin Equivalent/g and 28.82 mg Gallic acid equivalent/g of the extract respectively. The Gas Chromatography-Mass Spectrometric analysis detected hexadecanoic acid (43.09%) as the major component of the extract. A significant increase in parasitaemia was observed in the infected, untreated group, while the parasite was inhibited in both the chloroquine (CQ) and RPSE-treated groups. On day 8, treatment with 400 mg/kg of RPSE exhibited significant inhibition of parasitemia. However, the inhibitory effect of RPSE decreased after day 10. The 400 mg/kg treatment gave the greatest inhibition of P. berghei NK-65 (96.37% on Day 10), while the 100 mg/kg treatment resulted in the most significant effect on body weight (+1.64 g). Based on these findings, further studies would be required to establish RPSE as an invaluable addition to the list of plants that are involved in nature-based management of malaria infection.

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