Nwonuma, Charles Obiora and Abdurrahman, Jadesola Edna and Rotimi, Damilare Emmanuel and Evbuomwan, Ikponmwosa Owen and Lele, Kelechi Charity and Alejolowo, Omokolade Oluwaseyi and Ezea, Samson Chukwuemeka and Asogwa, Nnaemeka Tobechukwu and Oludipe, Emmanuel Olorunleke (2023) Theobroma cacao fortified-feed ameliorates potassium bromate-induced oxidative damage in male Wistar rat. Toxicology Reports, 10. pp. 269-280.
Full text not available from this repository.Abstract
Some therapeutic and beneficial health properties of the Theobroma cacao leaf have been documented. This study evaluated the ameliorative effect of Theobroma cacao-fortified feed against potassium bromate-induced oxidative damage in male Wistar rats. Thirty rats were randomly grouped into A-E. Except for E (the negative control), the rats in the other groups were administered 0.5 ml of 10 mg/kg body weight of potassium bromate daily using oral gavage and then allowed access to feed and water ad libitum. Groups B, C, and D were fed with 10 %, 20 %, and 30 % leaf-fortified feed respectively, while the negative and positive control (A) was fed with commercial feed. The treatment was carried out consecutively for fourteen days. In the liver and kidney, there was a significant increase (p < 0.05) in total protein concentration, a significant decrease (P < 0.05) in MDA level, and SOD activity in the fortified feed group compared to the positive control. Furthermore, in the serum, there was a significant increase (p < 0.05) in the albumin concentration, and ALT activity, and a significant decrease (p < 0.05) in urea concentration in the fortified feed groups compared to the positive control. The histopathology of the liver and kidney in the treated groups showed moderate cell degeneration compared to the positive control group. Antioxidant activity due to the presence of flavonoids and metal chelating activity of fiber in Theobroma cacao leaf could be responsible for the ameliorative effect of the fortified feed against potassium bromate-induced oxidative damage.
| Item Type: | Article |
|---|---|
| Subjects: | Q Science > Q Science (General) |
| Divisions: | Faculty of Medicine, Health and Life Sciences > School of Biological Sciences |
| Depositing User: | Mr Omokolade Alejolowo |
| Date Deposited: | 16 Feb 2026 09:18 |
| Last Modified: | 16 Feb 2026 09:18 |
| URI: | https://eprints.lmu.edu.ng/id/eprint/5998 |
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