Antioxidant status of rats administered silver nanoparticles orally

Adeyemi, O. S. and Faniyan, Temiloluwa Oluwashindara (2014) Antioxidant status of rats administered silver nanoparticles orally. Journal of Taibah University Medical Sciences, 9 (3). pp. 182-186.

Text 1-s2.0-S1658361214000377-main.pdf - Published Version Download (1MB)

Abstract

Silver nanoparticles are being used increasingly forbiomedical purposes because of their broad antimicrobialpotential. Their effects on cellular systems, however, havebeen addressed in only a few studies. We evaluated the ef-fects of these nanoparticles on the antioxidant status ofgroups of five male Wistar rats. Six groups of rats weregiven 100, 1000 or 5000 mg/kg daily through an oral can-nula for 7 or 14 days, one group received 5000 mg/kg for 21days, and a control group received distilled water. Theanimals were sacrificed 24 h after the end of treatment, andserum and tissue homogenates were prepared. Silvernanoparticles significantly (p<0.05) increased the con-centrations of malondialdehyde and superoxide dismutasebut decreased the levels of reduced glutathione, glutathioneS-transferase and catalase. These results indicate that silvernanoparticles may cause lipid peroxidation and alter anti-oxidant status in a manner that may cause oxidative stress.

Actions (login required)

View Item