Rat Plasma Metabolites and Renal Morphology Following Oral Exposure to a Polyherbal Mixture

Adeyemi, O. S. and Akinwande, O.V. (2015) Rat Plasma Metabolites and Renal Morphology Following Oral Exposure to a Polyherbal Mixture. Research Journal of Medicinal Plant, 9 (1). pp. 34-41. ISSN 1819-3455

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Abstract

Dearth of empirical evidence to support medicinal claims of several herbal mixtures fuelsgrowing safety concerns among the research community. Currently, there are no scientific data onFijk herbal mixture even though it enjoys wide patronage in Nigeria. This study was done toevaluate biochemical indices and renal morphology following oral and repeated exposure to Fijkherbal. Twenty-four male Wistar rats of weight between 195-210 g were randomly distributed intofour groups. Group 1 served as control and received distilled water only. Groups 2-4 received oraladministration of Fijk herbal at 15, 30 and 45 mg kgG, respectively. The treatment was daily and1lasted for 21 days, after which the animals were sacrificed under anesthesia. The blood and kidneytissues were collected and used for the biochemical determinations and histopathology examination.Exposure to Fijk herbal in rats caused elevated levels of plasma creatinine and urea relative to thecontrol. Likewise, levels of rat plasma potassium and sodium increased following oral exposure toFijk herbal. In contrast, the rat kidney weights as well as organ-to-body weight ratio weresignificantly decreased due to Fijk herbal exposure. The histopathology examinations revealedinflammation, swollen renal tubules and necrosis in groups exposed to Fijk herbal. Oral andrepeated exposure to Fijk herbal elevated rat biochemical indices and caused cellular lesionreminiscent of renal injury

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