The oral administration of silver nanoparticles activates the kynurenine pathway in rat brain independently of oxidative stress

Adeyemi, O. S. and Uloko, R. A. and Awakan, O. J. and Adeyanju, A. A. and Otohinoyi, D. A. (2019) The oral administration of silver nanoparticles activates the kynurenine pathway in rat brain independently of oxidative stress. Chemico-Biological Interactions, 302. pp. 22-27. ISSN 0009-2797

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Abstract

In this work, we determined whether oxidative stress contributed to the activation of the kynurenine pathway by AgNPs. Male Wistar rats weighing between 130 and 146 g were randomly assigned into six groups. Animals in the negative control group were orally administered distilled water while, the other treatment groups were respectively given AgNPs (25 and 50 mg/kg bw) alone or in combination with Trolox (100 mg/kg bw). Results showed that treatments with AgNPs signi fi cantly raised protein carbonyl level in rat liver, but the co-treatment with Trolox attenuated the elevation. Conversely, AgNPs raised the level of reduced glutathione (GSH) in rat plasma and tissues compared to the negative control. Further, oral exposure to AgNPs (50 mg/kg bw) sig- ni fi cantly elevated rat plasma and brain kynurenine levels compared to the negative control. Meantime, the co- treatment with Trolox appreciably restored kynurenine level in rat plasma, but not in the rat brain. Taken together, findings indicate that the oral administration of AgNPs alone at the doses used in this study, might not have caused oxidative stress. However, the co-treatment with Trolox appears to potentiate oxidative stress in rats following exposure to AgNPs. Furthermore, data support that the activation of the kynurenine pathway in the rat brain by AgNPs might be independent of oxidative stress. The fi ndings are new and contribute to deepen our understanding of the cellular interaction by nanoparticles

Item Type:	Article
Subjects:	T Technology > TP Chemical technology
Depositing User:	Mr DIGITAL CONTENT CREATOR LMU
Date Deposited:	26 Apr 2019 09:30
Last Modified:	26 Apr 2019 09:30
URI:	https://eprints.lmu.edu.ng/id/eprint/2131

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