Plasma concentrations of kidney function indicators in malaria patients in Ekpoma, South-South Nigeria

Idonije, B. O. and Nwoke, E. O and Festus, O. and Oluba, Olarewaju M. (2011) Plasma concentrations of kidney function indicators in malaria patients in Ekpoma, South-South Nigeria. International Journal of Tropical Medicine, 6 (1). pp. 4-7. ISSN 1816-3319

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Abstract

Malaria has protean clinical manifestations and Acute Renal Failure (ARF) is one of its serious complications and could be life threatening. Information on kidney involvement in malaria in Africa is still scanty and Nigeria is no exception. Kidney function was assessed in 60 (28 males and 32 females) malaria positive patients (as test subjects) and 40 (16 males and 24 females) malaria negative individuals (as controls) using plasma creatinine, urea and uric acid as test indicators. Descriptive analysis of results obtained showed that plasma creatinine level was significantly (p<0.05) increased in both males and females malaria positive patients (tests) compared to their respective controls (malaria negative males and females, respectively). Female test subjects also had significantly higher plasma urea concentration compared to female controls. No significant change (p>0.05) was observed in plasma uric acid between female test subjects and female control subjects. Similarly, plasma urea and uric acid levels were not significantly altered in male test subjects compared to male control subjects. Males test subjects were observed to have higher plasma levels of the test parameters compared to female test subjects. Comparative study between male and female test subjects showed significantly higher concentrations in plasma creatinine and uric acid in male test subjects compared to female test subjects. From these results, it is concluded that renal impairment is a clinical feature of malaria in Ekpoma, South-South Nigeria.

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