Phytochemical constituents and antidiarrhoeal effects of the aqueous extract of Terminalia superba leaves on Wistar rats

Bamisaye, F. A. and Odutuga, A. A. and Minari, J. B. and Dairo, J. O. and Fagbohunka, B. S. and Oluba, Olarewaju M. (2019) Phytochemical constituents and antidiarrhoeal effects of the aqueous extract of Terminalia superba leaves on Wistar rats. African Journal of Pharmacy and Pharmacology, 7 (16). pp. 848-851. ISSN 1996-0816

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Abstract

The aqueous extract of Terminalia superba leaves was subjected to phytochemical screening. Antidiarrhoeal property of the extract was determined at 50, 100 and 150 mg/kg body weight in castor oil-induced diarrhoeal Wistar rats. Phytochemical screening revealed the presence of saponins, cardenolides, triterpenes, flavonoids, steroids, phenolics and tannins, whereas alkaloids, anthraquinones and phlobatanins were not detected. The time of induction of diarrhoea was significantly (P < 0.05) prolonged at all the doses of the extract. The frequency of stooling and feacal parameters (total number of feaces and number of wet feaces), intestinal fluid accumulation (enteropooling) and the weight of intestinal content were significantly reduced. The data in the present study indicate that the aqueous extract of T. superba leaves possessed antidiarrhoeal properties. Key words: Phytochemicals, Terminalia superba, aqueous extract, diarrhoea, rats.

Item Type:	Article
Subjects:	Q Science > Q Science (General)
Depositing User:	Mr DIGITAL CONTENT CREATOR LMU
Date Deposited:	23 Sep 2019 13:38
Last Modified:	23 Sep 2019 13:38
URI:	https://eprints.lmu.edu.ng/id/eprint/2366

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