Archachatina marginata Haemolymph Potentiates Hypoglycemic Effect by Mimicking Insulin in Streptozotocin-Induced Diabetic Rat

Adeboye, S. K. and Ogundajo, A. T. and Ajayi, O. O. and Oluba, Olarewaju M. (2017) Archachatina marginata Haemolymph Potentiates Hypoglycemic Effect by Mimicking Insulin in Streptozotocin-Induced Diabetic Rat. JOURNAL OF PHARMACEUTICAL RESEARCH INTERNATIONAL, 18 (1). pp. 1-8. ISSN 2231-2919

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Abstract

Aims: This study investigates the hypoglycemic potential of Archachatina marginata haemolymph and its mechanism in streptozotocin -induced diabetic rats. Study Design: One factor experimental design. Place and Duration of Study: Department of Chemical Sciences, Joseph Ayo Babalola University, Ikeji Arakeji, Osun State, Nigeria between January to June, 2015. Methodology: The rats were set into four groups (n=5). Group 1 - Non-diabetic control (NDC), Group 2 - Diabetic Control (DC), Group 3 - Diabetic rats with 1 mL administration of snail Original Research Article Adeboye et al.; JPRI, 18(1): 1-8, 2017; Article no.JPRI.33786 2 haemolymph (DSS1), Group 4 - Diabetic rats with 2 mL snail haemolymph administration (DSS2). The blood glucose concentration of each rat was taken and thereafter, they were weighed and then administered with 55 mg/kg STZ in citrate buffer (pH 4.5) peritoneally non-diabetic control group (NDC). Rats with blood glucose level of 200 mg/dL and above were considered diabetic. Haemolymph of 1 mL and 2 mL were administered to rats in DSS1 and DSS2 respectively while DC received 2 mL distilled water for 14 consecutive days. Physiological orangs and blood samples were harvested for various analysis. Results: The A. marginata haemolymph significantly improved the plasma concentration of insulin and reduced plasma glucose level in a dose dependent manner P=.05. Conclusion: The A. marginata haemolymph has potential to exact hypoglycemic effect and improve the insulin concentration in streptozotocin induced diabetic rat. Keywords: Archachatina marginata; haemolymph; streptozocin diabetes rats.

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