Ivermectin Protects against Monosodium Glutamate-Induced Excitotoxicity in the Rat

Arise, Rotimi Olusanya and Arise, Abimbola K. and Oyewole, Oluwole I. and Malomo, S.O. (2019) Ivermectin Protects against Monosodium Glutamate-Induced Excitotoxicity in the Rat. Acta Facultatis Medicae Naissensis, 36 (1). pp. 38-47.

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Monosodium glutamate (MSG), an established excitotoxic food additive, has been found to induce oxidative stress in all tissues. To examine the protective effects of ivermectin on MSG-induced excitotoxicity, 28 male albino rats were randomized into four groups. Group 1, the control, received 1 ml of oral distilled water, group 2 was administered an aqueous solution of MSG (4 mg/kg body weight/day). Group 3 was co-administered with the same dose of MSG and 0.4 mg/kg body weight of ivermectin, while group 4 rats received orally the same dose of MSG for 2 weeks, after which ivermectin was administered orally for 1 week. Administration of MSG orally for 21 days and for 14 days, followed by oral administration of ivermectin for 7 days, significantly increased (p < 0.05) glutathione-S-transferase, nitric oxide synthase, superoxide dismutase and catalase activities as well as malondialdehyde and intracellular Ca2+ concentrations while Na+ - K+ - ATPase, Ca2+ - Mg2+ - ATPase, acid phosphatase (ACP) and alkaline phosphatase (ALP) activities were significantly reduced (p < 0.05) compared to the control. However, co-administration of MSG and ivermectin for 21 days did not show any significant difference (p > 0.05) in all the parameters studied compared to the control. This result suggests that ivermectin may protect against MSG-induced excitotoxicity in rats.

Item Type: Article
Subjects: Q Science > QD Chemistry
Q Science > QH Natural history > QH301 Biology
Date Deposited: 23 Sep 2019 08:39
Last Modified: 23 Sep 2019 08:39
URI: https://eprints.lmu.edu.ng/id/eprint/2342

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