Lemon Juice Elevated Level of Reduced Glutathione and Improved Lipid Profile in Wistar Rats

Olukanni, O.D. and Akande, O.T. and Alagbe, Y.O. and Adeyemi, O. S. and Olukann, A.T. and Daramola, G.G. (2013) Lemon Juice Elevated Level of Reduced Glutathione and Improved Lipid Profile in Wistar Rats. American-Eurasian J. Agric. & Environ. Sci, 13 (9). pp. 1246-1251. ISSN 1818-6769

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Abstract

The beneficial uses of lemon juice have been reported from ages. Such uses are however more ofspeculations than investigation. In this study, the actions of lemon juice on antioxidant status and lipid profilein wistar rats were investigated. Thirty rats were randomized into two groups of fifteen rats each. The first group(control) received distilled water and the second group was given lemon (10% in water), daily for five weeksin addition to the rat chow diet. Serum total protein, reduced glutathione (GSH), catalase (CAT), superoxide(SOD) levels were determined as antioxidant status, while total cholesterol, LDL-cholesterol, HDL-cholesteroland triglycerides were measured as the lipid profile. The resultof the antioxidant status showed significantincrease (p<0.05) in the GSH levels of the lemon treated group (0.63±0.01 μg/ml/mg protein) relative to thecontrol (0.53±0.03 μg/ml/mg protein) after 5 week of lemon intake. The lipid profile improved as shown by thesignificant reduction of total cholesterol, LDL-cholesterol and significant increase in HDL cholesterol.The elevation of serum GSH could be responsible in part for the reported antioxidant effects of lemon juice.It is possible that one or more components in the administered lemon juice stimulated the production of GSHor the reduction of GSSG to GSH

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