Polyphenolic content and biochemical evaluationof fijk, alomo, osomo and oroki herbal mixturesin vitro

Adeyemi, O. S. and Owoseni, M.C. (2015) Polyphenolic content and biochemical evaluationof fijk, alomo, osomo and oroki herbal mixturesin vitro. Beni-Suef University Journal of Basic and Applied Sciences, 4. pp. 200-206.

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The current upsurge in the use of herbal remedies coupled with loose regu-lation on public access to these products underscore research efforts to evaluate theirbiochemical effect, noting also that many of the herbal medicines lack scientific credenceto support medicinal claims.Objective:Determination ofin vitroantioxidant capacity and membrane stabilizing poten-tial of some herbal remedies (Fijk, Osomo, Alomo and Oroki) respectively.Methodology:Red blood cells (RBCs) were prepared from rat blood and exposed to the thera-peutic doses of Fijk, Alomo, Osomo and Oroki herbals in order to estimate relative hemolysis.Distilled water treatment of RBCs was taken as 100% hemolysis. Subsequently, the hemolysateswere used for the determination of glucose-6-phosphate dehydrogenase (G6PD), superox-ide dismutase (SOD), reduced glutathione (GSH) and malondialdehyde (MDA). The herbalswere further evaluated for their polyphenolic content, free radical scavenging activity aswell as total antioxidant capacity.Results:The herbals showed low polyphenolic content, reduced antioxidant capacity andoffered no protection against free radical-induced degradation of deoxyribose. On the otherhand, the herbal mixtures caused appreciable hemolysis of RBCs as well as depleted thelevels of rat erythrocyte G6PD, GSH and SOD. Also, the erythrocyte level of MDA was el-evated (p<0.05) by exposure to Oroki herbal mixture.Conclusion:The herbal mixtures have low polyphenolic content as well as poor antioxi-dant property. This may impede their capacity to protect against oxidative stress.

Item Type: Article
Subjects: Q Science > QH Natural history > QH426 Genetics
Date Deposited: 16 Sep 2019 10:47
Last Modified: 16 Sep 2019 10:47
URI: https://eprints.lmu.edu.ng/id/eprint/2222

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