Inorganic nanoparticles kill Toxoplasma gondiivia changes in redox status and mitochondrial membrane potential

Adeyemi, O. S. and Murata, Yuho and Sugi, Tatsuki and Kato, Kentaro (2019) Inorganic nanoparticles kill Toxoplasma gondiivia changes in redox status and mitochondrial membrane potential. International Journal of Nanomedicine, 12. pp. 1647-1661.

Text ijn-12-1647.pdf - Accepted Version Download (3MB)

Abstract

This study evaluated the anti-Toxoplasma gondii potential of gold, silver, and platinum nanoparticles (NPs). Inorganic NPs (0.01–1,000 μg/mL) were screened for antiparasitic activity. The NPs caused .90% inhibition of T. gondii growth with EC50 values of #7, #1, and #100 μg/mL for gold, silver, and platinum NPs, respectively. The NPs showed no host cell cytotoxicity at the effective anti-T. gondii concentrations; the estimated selectivity index revealed a $20-fold activity toward the parasite versus the host cell. The anti-T. gondii activity of the NPs, which may be linked to redox signaling, affected the parasite mitochondrial mem-brane potential and parasite invasion, replication, recovery, and infectivity potential. Our results demonstrated the antiparasitic potential of NPs. The findings support the further exploration of NPs as a possible source of alternative and effective anti-T. gondii agents

Actions (login required)

View Item