Hypoxia-Inducible Factors as an Alternative Source of TreatmentStrategy for Cancer

Akanji, Musbau Adewumi and Rotimi, Damilare E. and Adeyemi, O. S. (2019) Hypoxia-Inducible Factors as an Alternative Source of TreatmentStrategy for Cancer. Oxidative Medicine and Cellular Longevity.

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Abstract

Hypoxia-inducible factors (HIFs) are transcription factors that activate the transcription of genes necessary to circumvent tohypoxic (low oxygen level) environments. In carcinogenesis, HIFs play a critical role. Indeed, HIF-1αhas been validated as apromising target for novel cancer therapeutics, even as clinical investigations have linked increased levels of HIF-1αwithaggressive cancer progression as well as poor patient prognosis. More so, inhibiting HIF-1 activity restricted cancer progression.Therefore, HIF-1 is a viable target for cancer therapy. This may be expected considering the fact that cancer cells areknown to be hypoxic. In order to survive the hypoxic microenvironment, cancer cells activate several biochemicalpathways via the HIF-1α. Additionally, cellular and molecular insights have proved prospects of the HIF-1αpathway forthe development of novel anticancer treatment strategies. The biochemical importance of hypoxia-inducible factors (HIFs)cannot be overemphasized as carcinogenesis, cancer progression, and HIFs are intricately linked. Therefore, this reviewhighlights the significance of these linkages and also the prospects of HIFs as an alternative source of cancer therapies

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