Modulation of rat plasma kynurenine level by platinum nanoparticles and likely association with oxidative stres

Adeyemi, O. S. and Olajide, I. O. and Adeyanju, A. A. and Awakan, O. J. and Otohinoyi, D. A. (2018) Modulation of rat plasma kynurenine level by platinum nanoparticles and likely association with oxidative stres. Biointerface Research in Applied Chemistry, 8 (4). pp. 3364-3367. ISSN 2069-5837

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Abstract

In this study, we investigated whether oxidative stress contributes to activation of kynurenine pathway by platinum nanoparticles (PtNPs). Thirty male Wistar rats with an average weight between 126 – 130 g were randomly assigned into six groups. The negative control group was orally administered distilled water while the other treatment groups respectively received oral administration of either PtNPs (25 and 50 mg/kg bw) singly or in combination with ascorbic acid (100 mg/kg bw). Results revealed that oral administration of PtNPs did not cause lipid peroxidation in rat brain and plasma relative to negative control. In contrast, PtNPs elevated protein carbonyl levels in rat plasma relative to negative control. In the meantime, the level of reduced glutathione (GSH) in rat tissues was maintained when compared with negative control and PtNPs alone. However, plasma GSH was significantly (p<0.05) increased by PtNPs at both doses used and co-treatment with ascorbic acid. Oral exposure to PtNPs and ascorbic acid elevated kynurenine level in rat plasma. Taken together, data indicated that PtNPs given alone at the doses investigated might not have caused oxidative stress in rat tissues and plasma but co-treatment with ascorbic acid appeared to potentiate capacity to elevate oxidative stress markers. Further, elevation of kynurenine level in rat plasma by PtNPs might be connected with oxidative stress since PtNPs did elevate protein carbonyl level and co-treatment with ascorbic acid modulated the kynurenine level.

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