Metal nanoparticles restrict the growth of protozoan parasites

Adeyemi, O. S. and Molefe, Nthatisi Innocentia and Awakan, O. J. and Nwonuma, C.O. and Alejolowo, Omokolade Oluwaseyi and Olaolu, D.T. and Maimako, Rotdelmwa Filibus and Suganuma, Keisuke and Han, Yongmei and Kato, Kentaro (2018) Metal nanoparticles restrict the growth of protozoan parasites. ARTIFICIAL CELLS, NANOMEDICINE, AND BIOTECHNOLOGY, 46 (53). pp. 586-594. ISSN 2169-1401; 2169-141X

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TheTrypanosomaandToxoplasma spp, are etiological agents of diseases capable of causing significantmorbidity, mortality and economic burden, predominantly in developing countries. Currently, there areno effective vaccines for the diseases caused by these parasites; therefore, therapy relies heavily onantiprotozoal drugs. However, the treatment options for these parasitic diseases are limited, thusunderscoring the need for new anti-protozoal agents. Here, we investigated the anti-parasite action ofnanoparticles. We found that the nanoparticles have strong and selectivein vitroactivity againstT. b. bruceibut moderatein vitroactivity againstT. congolenseandT. evansi. An estimation of thein vitroanti-Trypanosomaefficacy showed that the nanoparticles had�200-fold selective activityagainst the parasite versus mammalian cells. Moreover, the nanoparticle alloys moderately suppressedthein vitrogrowth ofT. gondiiby�60%. In ourin vivostudy, the nanoparticles appeared to exhibit atrypanostatic effect, but did not totally suppress the rat parasite burden, thereby failing to appreciablyextend the survival time of infected animals compared with the untreated control. In conclusion, this isthe first study to demonstrate the selectivein vitroanti-Trypanosomaaction of nanoparticles and thussupports the potential of nanoparticles as alternative anti-parasitic agents.

Item Type: Article
Subjects: Q Science > QH Natural history > QH301 Biology
Date Deposited: 24 Apr 2019 15:33
Last Modified: 16 Sep 2019 10:36

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