The burden of disease attributable to ambient PM2.5-bound PAHs exposure in Nagpur, India

Etchie, Tunde O. and Sivanesan, Saravanadevi and Etchie, Ayotunde T. and Adewuyi, Gregory O. and Krishnamurthi, Kannan and George, K.V. and Rao, Padma S. (2018) The burden of disease attributable to ambient PM2.5-bound PAHs exposure in Nagpur, India. Chemosphere, 204. pp. 277-289.

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Exposure to PM2.5-bound polycyclic aromatic hydrocarbons (PAHs) can elicit several types of cancer and non-cancer effects. Previous studies reported substantial burdens of PAH-induced lung cancer, but the burdens of other cancer types and non-cancer effects remain unknown. Thus, we estimate the cancer and non-cancer burden of disease, in disability-adjusted life years (DALYs), attributable to ambient PM2.5-bound PAHs exposure in Nagpur district, India, using risk-based approach. We measured thirteen PAHs in airborne PM2.5 sampled from nine sites covering urban, peri-urban and rural areas, from February 2013 to June 2014. We converted PAHs concentrations to benzo[a]pyrene equivalence (B[a]Peq) for cancer and non-cancer effects using relative potency factors, and relative toxicity factors derived from quantitative structure-activity relationships, respectively. We calculated time-weighted exposure to B[a]Peq, averaged over 30 years, and adjusted for early-life susceptibility to cancer. We estimated the DALYs/year using B[a]Peq exposure levels, published toxicity data, and severity of the diseases from Global Burden of Disease 2016 database. The annual average concentration of total PM2.5-bound PAHs was 458±246 ng/m3 and resulted in 49,500 DALYs/year (0.011 DALYs/person/year). The PAH-related DALYs followed this order: developmental (mostly cardiovascular) impairments (55.1%) > cancer (26.5%) or lung cancer (23.1%) > immunological impairments (18.0%) > reproductive abnormalities (0.4%).

Item Type: Article
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Depositing User: Dr Tunde Ogbemi Etchie
Date Deposited: 30 Nov 2018 16:55
Last Modified: 30 Nov 2018 16:55

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