EVALUATION OF THE EFFECT OF ANCHOMANES DIFFORMIS ROOT AND BLACK SOAP MIXTURE ON UTERINE FUNCTION INDICES OF RATS

Olaolu, D.T. and Okedare, V.A. and Akpor, O.B. (2016) EVALUATION OF THE EFFECT OF ANCHOMANES DIFFORMIS ROOT AND BLACK SOAP MIXTURE ON UTERINE FUNCTION INDICES OF RATS. CIBTech Journal of Zoology, 5 (3). pp. 19-28. ISSN 2319–3883

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Abstract

This study was aimed at investigating the effect of aqueous infusion of Anchomanes difformis root-black soap mixture on uterine function indices in Wistar rats. Twenty female albino rats (Rattus norvegicus) weighing 120-130 g were randomized into 4 subgroups, A – D. Animals in these subgroups received 1 ml of distilled water (control), 0.02, 0.04 and 0.08 ml/kg body weight of aqueous infusion of Anchomanes difformis root-black soap mixture respectively. Oral administration to the animals was done once daily for 7 days. Administration of aqueous A. difformis root-black soap mixture at all the doses resulted in significant increase (P <0.05) in uterus–body weight ratio, uterine glucose, protein, cholesterol, alkaline phosphatase, serum estradiol, luteinizing hormone and follicle stimulating hormones. This increase was observed to be 171 kg, 0.06 mg/ml, 169 mg/ml, 158 mg/ml, 14.53 nM/min/ml, 58.9 mg/ml, 26.5 mIU/ml and 56.9 mIU/ml respectively compared with control levels of 98.3 kg, 0.02 mg/ml, 100 mg/ml, 99.7 mg/ml, 14.5 nM/min/ml, 10 mg/ml, 8 mIU/ml and 8 mIU/ml respectively. It may be concluded from this study that the oral administration of aqueous infusion of A. difformis root-black soap mixture has the ability to increase the synthesis of female hormones and uterine function indices leading to a general enhancement in the functioning of the uterus.

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